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Phase I trials - memoinOncology
Phase I trials - memoinOncology

Outline
Outline

Dose-finding clinical trial design for ordinal toxicity grades using the continuation ratio model: an extension of the continual reassessment method - Emily M Van Meter, Elizabeth Garrett-Mayer, Dipankar Bandyopadhyay, 2012
Dose-finding clinical trial design for ordinal toxicity grades using the continuation ratio model: an extension of the continual reassessment method - Emily M Van Meter, Elizabeth Garrett-Mayer, Dipankar Bandyopadhyay, 2012

Study flow chart. DLT, dose-limiting toxicity. | Download Scientific Diagram
Study flow chart. DLT, dose-limiting toxicity. | Download Scientific Diagram

Study design. PK, pharmacokinetics; DLT, dose- limiting toxicity | Download Scientific Diagram
Study design. PK, pharmacokinetics; DLT, dose- limiting toxicity | Download Scientific Diagram

Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): A multicentre, open-label, dose-escalation phase 1 trial - eClinicalMedicine
Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): A multicentre, open-label, dose-escalation phase 1 trial - eClinicalMedicine

Single-arm, open-label, dose-escalation phase I study to evaluate the safety of a herbal medicine SH003 in patients with solid cancer: a study protocol | BMJ Open
Single-arm, open-label, dose-escalation phase I study to evaluate the safety of a herbal medicine SH003 in patients with solid cancer: a study protocol | BMJ Open

DLT - Dose Limiting Toxicity - determined by phase 1 studies
DLT - Dose Limiting Toxicity - determined by phase 1 studies

1. Given the true DLT rate, calculate the probability | Chegg.com
1. Given the true DLT rate, calculate the probability | Chegg.com

Study design for dose-escalation cohorts and DLT rate (as calculated by... | Download Scientific Diagram
Study design for dose-escalation cohorts and DLT rate (as calculated by... | Download Scientific Diagram

Dose escalation algorithm for trial part 1. DLT, dose-limiting... | Download Scientific Diagram
Dose escalation algorithm for trial part 1. DLT, dose-limiting... | Download Scientific Diagram

Study protocol: phase 1 dose escalating study of Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) with oxaliplatin in peritoneal metastasis
Study protocol: phase 1 dose escalating study of Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) with oxaliplatin in peritoneal metastasis

collezione privata quadro - DLT Dose Limiting Toxicity - Giselle Treccarichi | PitturiAmo® APS
collezione privata quadro - DLT Dose Limiting Toxicity - Giselle Treccarichi | PitturiAmo® APS

BOIN Suite: A Software Platform to Design and Implement Novel Early-Phase Clinical Trials | JCO Clinical Cancer Informatics
BOIN Suite: A Software Platform to Design and Implement Novel Early-Phase Clinical Trials | JCO Clinical Cancer Informatics

Entropy | Free Full-Text | Escalation with Overdose Control is More Efficient and Safer than Accelerated Titration for Dose Finding
Entropy | Free Full-Text | Escalation with Overdose Control is More Efficient and Safer than Accelerated Titration for Dose Finding

A Multicenter Phase I/II Study of Obatoclax Mesylate Administered as a 3- or 24-Hour Infusion in Older Patients with Previously Untreated Acute Myeloid Leukemia | PLOS ONE
A Multicenter Phase I/II Study of Obatoclax Mesylate Administered as a 3- or 24-Hour Infusion in Older Patients with Previously Untreated Acute Myeloid Leukemia | PLOS ONE

Is more better? An analysis of toxicity and response outcomes from dose-finding clinical trials in cancer | BMC Cancer | Full Text
Is more better? An analysis of toxicity and response outcomes from dose-finding clinical trials in cancer | BMC Cancer | Full Text

1. In a typical Phase I clinical trial of a new drug, | Chegg.com
1. In a typical Phase I clinical trial of a new drug, | Chegg.com

Illustration of the chronic dose-limiting toxicity (DLT) concept. (*)... | Download Scientific Diagram
Illustration of the chronic dose-limiting toxicity (DLT) concept. (*)... | Download Scientific Diagram

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Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study. - Abstract - Europe PMC
Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study. - Abstract - Europe PMC

Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study - ScienceDirect
Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study - ScienceDirect

DURVIT': a phase-I trial of single low-dose durvalumab (Medi4736) IntraTumourally injected in cervical cancer: safety, toxicity and effect on the primary tumour- and lymph node microenvironment | BMC Cancer | Full Text
DURVIT': a phase-I trial of single low-dose durvalumab (Medi4736) IntraTumourally injected in cervical cancer: safety, toxicity and effect on the primary tumour- and lymph node microenvironment | BMC Cancer | Full Text

Would the Recommended Dose Have Been Different Using Novel Dose-Finding Designs? Comparing Dose-Finding Designs in Published Trials | JCO Precision Oncology
Would the Recommended Dose Have Been Different Using Novel Dose-Finding Designs? Comparing Dose-Finding Designs in Published Trials | JCO Precision Oncology

Flexibility of the BLRM in Dose-Escalation Trials
Flexibility of the BLRM in Dose-Escalation Trials

Three-plus-three dose escalation design. DLT, dose-limiting toxicity;... | Download Scientific Diagram
Three-plus-three dose escalation design. DLT, dose-limiting toxicity;... | Download Scientific Diagram